Evaluate the Safety, Immunologic, and Virologic Responses of Donor Derived (DD) HIV-Specific T-cells (HST) in HIV-infected Individuals Following Allogeneic Bone Marrow Transplantation (alloRESIST)

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

8

Participants

Timeline

Start Date

May 1, 2020

Primary Completion Date

September 30, 2025

Study Completion Date

April 30, 2026

Conditions
HIV-Infected Individuals
Interventions
BIOLOGICAL

DD HST-NEETs

HIV-infected individuals following Allogeneic Bone Marrow Transplantation (alloBMT) will be treated with DD HST-NEETS therapy. Participants and donors will be screened for eligibility. Eligible donors will undergo a blood draw of up to 300mL to allow production of allogeneic DD HST-NEETs. Participants, who meet specified inclusion criteria including neutrophil recovery post-transplant and for whom donor products have passed release testing, will receive DD HST-NEETs at a dose of 2x107/m2 within 30 days of screening visit.

Trial Locations (1)

21231

Johns Hopkins University(Jhu), Baltimore

All Listed Sponsors
lead

Catherine Bollard

OTHER