Prehabilitation and Posttransplant Training Program in Liver Transplantation

NAEnrolling by invitationINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

April 1, 2021

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Liver Transplant; ComplicationsCirrhosis, LiverHepatic Carcinoma
Interventions
OTHER

Prehabilitation

Supervised training program of 8-weeks and a frequency of 2 days/week. It includes interval aerobic exercise (5 cycles of 2 minutes at 70 percentage of Watts or heart rate of cardiopulmonary exercise testing (CEPT) and 3 minutes of active rest at 40 percentage; peripheral muscle training and balance exercises in a circuit of 10 phases, 10 to 15 repetitions, from 1 to 3 sets (the participants will work at moderate intensity, no more than 5-6/10 on the modified Borg scale); Inspiratory Muscle Training (IMT) through a threshold loading device \[2 sessions / day, 3 sets of 15 repetitions, at 60-70 percentage of the maximum inspiratory pressure (cmH2O)\]; ventilatory reeducation by an incentive inspirator based on the vital capacity evaluated in the initial spirometry. Both the aerobic modality and the resistance training, will increase the intensity of work (HR, Watts, Kg or cmH2O) between 2-5 percentage every 2 weeks complying with the principle of training overload.

OTHER

Prehabilitation and posttransplant training program

Prehabilitation will be followed by a posttransplant training program. In this, the patient will perform supervised exercise (IIa interval aerobic exercise and resistance training) 2 days / week, and a physical exercise program at home until completing a total of 5 sessions / week in the aerobic modality. In the unsupervised phase (IIb), the patient will continue with the learned physical exercise program, but without supervision, 5 sessions / week (including a minimum of 2 non-consecutive sessions to perform resistance training).

Trial Locations (1)

46026

Hospital Universitari i Politècnic La Fe, Valencia

All Listed Sponsors
collaborator

University of Valencia

OTHER

lead

Maria dels Angels Cebria i Iranzo, PT, PhD

OTHER