Study of SX-682 Alone and in Combination with Oral or Intravenous Decitabine in Subjects with Myelodysplastic Syndrome

PHASE1RecruitingINTERVENTIONAL
Enrollment

151

Participants

Timeline

Start Date

June 30, 2020

Primary Completion Date

March 31, 2028

Study Completion Date

March 31, 2029

Conditions
Myelodysplastic Syndromes
Interventions
DRUG

SX-682

SX-682 is an oral small molecule selective inhibitor of C-X-C Motif Chemokine Receptor 1 (CXCR1) and CX-C Motif Chemokine Receptor 2 (CXCR2)

DRUG

Decitabine

Decitabine is a hypomethylating agent.

Trial Locations (7)

10467

RECRUITING

Montefiore Medical Center, The Bronx

21287

RECRUITING

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

30322

RECRUITING

Emory University, Atlanta

32224

RECRUITING

Mayo Clinic, Jacksonville

32804

RECRUITING

AdventHealth Medical Group & Bone Marrow Transplant at Orlando, Orlando

33136

RECRUITING

University of Miami, Miami

33612

RECRUITING

Moffitt Cancer Center, Tampa

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

H. Lee Moffitt Cancer Center and Research Institute

OTHER

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

AdventHealth

OTHER

collaborator

Emory University

OTHER

collaborator

University of Miami

OTHER

collaborator

Mayo Clinic

OTHER

collaborator

Montefiore Medical Center

OTHER

collaborator

National Cancer Institute (NCI)

NIH

collaborator

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

OTHER

lead

Syntrix Biosystems, Inc.

INDUSTRY

NCT04245397 - Study of SX-682 Alone and in Combination with Oral or Intravenous Decitabine in Subjects with Myelodysplastic Syndrome | Biotech Hunter | Biotech Hunter