A Trial of the Efficacy and Safety of CVL-865 as Adjunctive Therapy in the Treatment of Focal Onset Seizures

PHASE2CompletedINTERVENTIONAL
Enrollment

154

Participants

Timeline

Start Date

January 27, 2020

Primary Completion Date

May 21, 2024

Study Completion Date

May 21, 2024

Conditions
Seizures
Interventions
DRUG

Placebo

Participants received CVL-865 matched placebo tablets orally twice a day (BID) during the Treatment Period.

DRUG

CVL-865

Participants received CVL-865 tablets orally twice a day (BID) up to the maximum dose of 7.5 mg BID or 25 mg BID during the Treatment Period.

Trial Locations (76)

2031

Randwick, New South Wales, Randwick

2050

Camperdown, New South Wales, Camperdown

2145

Westmead, New South Wales, Westmead

3004

Melbourne, Victoria, Melbourne

3050

Parkville, Victoria, Parkville

3065

Fitzroy, Victoria, Fitzroy

3084

Heidelberg, Victoria, Heidelberg

4029

Herston, Queensland, Herston

4101

South Brisbane, Queensland, South Brisbane

8035

Barcelona, Barcelona

10021

New York, New York

11000

Belgrade, Belgrade

Clinic of Neurology, Belgrade, Belgrade

11501

Mineola, New York, Mineola

13210

Syracuse, New York, Syracuse

14642

Rochester, New York, Rochester

18000

Niš, Niš

19104

Philadelphia, Pennsylvania, Philadelphia

19107

Philadelphia, Pennsylvania, Philadelphia

20817

Bethesda, Maryland, Bethesda

21287

Baltimore, Maryland, Baltimore

28027

Madrid, Madrid

28034

Madrid, Madrid

28040

Madrid, Madrid

29010

Malaga,, Málaga

29425

Charleston, South Carolina, Charleston

30024

Suwanee, Georgia,, Suwanee

31008

Navarra, Navarro

32127

Port Orange, Florida, Port Orange

32224

Jacksonville, Florida, Jacksonville

32714

Altamonte Springs, Florida, Altamonte Springs

32806

Orlando, Florida, Orlando

33016

Miami Lakes, Florida, Miami Lakes

33032

Homestead, Florida, Homestead

33136

Miami, Florida, Miami

33606

Tampa, Florida, Tampa

33952

Port Charlotte, Florida, Port Charlotte

34000

Kragujevac, Sumadija, Kragujevac

Neurology Department, Kragujevac, Kragujevac

37232

Nashville, Tennessee, Nashville

40504

Lexington, Kentucky, Lexington

41013

Sevilla, Seville

43221

Columbus, Ohio, Columbus

43614

Toledo, Ohio, Toledo

46026

Valencia, Valencia

63005

Chesterfield, Missouri, Chesterfield

63110

Saint Louis, Missouri, St Louis

72205

Little Rock, Arkansas, Little Rock

73112

Oklahoma City, Oklahoma, Oklahoma City

79035

Lviv, Lviv

84108

Salt Lake City, Utah, Salt Lake City

88018

Uzhgorod, Uzhhorod

90242

Downey, California, Downey

91355

Valencia, California, Valencia

92354

Loma Linda, California, Loma Linda

96817

Honolulu, Hawaii, Honolulu

06520

New Haven, Connecticut, New Haven

32561-4458

Gulf Breeze, Florida, Gulf Breeze

04074

Scarborough, Maine, Scarborough

02114

Boston, Massachusetts, Boston

07601

Hackensack, New Jersey, Hackensack

85-163

Bydgoszcz, Kujawsko-Pomorskie, Bydgoszcz

31-209

Kraków, Malopolskie, Krakow

02-119

Warszawa, Mazowieckie, Warsaw

80-546

Gdańsk, Pomorskie, Gdansk

80-803

Gdańsk, Pomorskie, Gdansk

40-650

Wojnicz, Lskie, Wojnicz

15-704

Białystok, Bialystok

20-078

Lublin, Lublin

02-952

Warszawa, Warsaw

90-752

Lodz, Lodz

05030

Gwangjin-gu, Seoul, Gwangju

06351

Irwon-Ro Gangnam-gu., Seoul, Irwon-dong

08003

Barcelona, Catalunya, Barcelona

08222

Terrassa, Terrassa

02091

Kyiv, Kyiv

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