A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

PHASE1RecruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

January 15, 2020

Primary Completion Date

December 19, 2025

Study Completion Date

March 25, 2026

Conditions
Hepatic ImpairmentAdvanced Malignant Solid Tumor
Interventions
DRUG

Tazemetostat

"Tazemetostat (EPZ-6438) in tablet form at a dose of 800 mg once daily on days 1 and 15 and twice daily on days 5 to 14 of the first 28-day cycle.~Participants may continue tazemetostat treatment at 800 mg twice daily in additional 28-day cycles until progression or unacceptable toxicity."

Trial Locations (18)

1200

WITHDRAWN

Cliniques Universitaires Saint-Luc, Brussels

2650

TERMINATED

Antwerp University Hospital, Edegem

13005

WITHDRAWN

Hopital de la Timone, Marseille

22031

RECRUITING

Virginia Cancer Specialists, Fairfax

32746

COMPLETED

Florida Cancer Specialists & Research Institute, Lake Mary

33076

TERMINATED

Institut Bergonie, Bordeaux

44718

COMPLETED

Gabrail Cancer Center, Canton

48073

COMPLETED

Hematology Oncology Consultants, Royal Oak

59020

TERMINATED

Centre Oscar Lambret, Lille

60611

COMPLETED

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago

60693

TERMINATED

MedPolonia, Poznan

75230

COMPLETED

Mary Crowley Cancer Research, Dallas

77030

WITHDRAWN

Oncology Consultants - Texas Medical Center, Houston

89014

COMPLETED

Comprehensive Cancer Center of Nevada, Las Vegas

08901

RECRUITING

Rutgers Cancer Institute, New Brunswick

Unknown

TERMINATED

Institut de Cancérologie Strasbourg Europe, Strasbourg

05410

WITHDRAWN

Biokinetica S.A Przychodnia Jozefow, Józefów

831 01

TERMINATED

Summit Clinical Research, s.r.o, Bratislava

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Sponsor GmbH

OTHER

lead

Epizyme, Inc.

INDUSTRY