CD19-CART in the Treatment of R/R CD19 Positive Non-Hodgkin's Lymphoma

NAUnknownINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

May 31, 2019

Primary Completion Date

June 15, 2019

Study Completion Date

May 31, 2021

Conditions
Non Hodgkin Lymphoma
Interventions
BIOLOGICAL

CD19 CAR-T cells infusion

"Biological: CD19 CAR-T cells infusion Biological: CD19 CAR-T cells infusion. Pretreatment: patients enrolled in this study will receive cyclophosphamide or fludarabine plus cyclophosphamide. CD19 CAR-T cells infusion are allowed within 2 weeks after treatment.~CD19 CAR-T cells infusion: 30-60 minutes before infusion, H1 anti-histamine agents are applied (acetaminophen 30mg,po.; promethazine 25mg,i.v. ; diphenhydramine 0.5-1mg/kg, no more than 50mg.). Non-physiological doses of corticosteroids are not applied for patients during treatment or recovery unless a life-threatening emergency occurs. CD19 CAR-T cells are infused into patients for one time, the number of infused CD19 CAR-T cells are 0.5-4×10\^6/kg."

Trial Locations (1)

450000

RECRUITING

First Affiliated Hospital of Zhengzhou University, Zhengzhou

All Listed Sponsors
collaborator

The First Affiliated Hospital of Zhengzhou University

OTHER

lead

PersonGen BioTherapeutics (Suzhou) Co., Ltd.

INDUSTRY