NCT04231708View on ClinicalTrials.gov

Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

June 30, 2025

Primary Completion Date

October 31, 2027

Study Completion Date

December 31, 2027

Conditions
Opioid Use Disorder
Interventions
DRUG

Yohimbine + Hydrocortisone

Yohimbine (54mg bulk powder inside capsule) administered in combination with Hydrocortisone (20mg tablet inside capsule)

DEVICE

Active rTMS

10Hz rTMS over the left dlPFC

DRUG

Placebo

lactose (inside capsule)

DEVICE

Sham rTMS

inactive stimulation over the left dlPFC

Trial Locations (1)

48201

Tolan Park Medical Building, Detroit

All Listed Sponsors
lead

Wayne State University

OTHER