A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy (HB-adMSCs) for the Treatment of Alzheimer's Disease

PHASE1/PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

March 1, 2020

Primary Completion Date

February 1, 2022

Study Completion Date

February 1, 2022

Conditions
Alzheimer Disease
Interventions
BIOLOGICAL

HB-adMSCs

Four IV infusions of autologous adipose-derived mesenchymal stem cells. Baseline laboratory data will be collected prior to first infusion; follow-up data will be compared against baseline according to the following schedule: safety laboratory tests follow-up on weeks 4, 8, 13, 26, and 52; inflammation and amyloid markers follow-up on weeks 13 and 52; MMSE and ADCS-ADL follow-up on weeks 13, 19, 26, 33, 40, 46 and 52; Altoida NMI follow-up will occur weekly from week 0 to week 52; CDR follow-up will occur weeks 4, 10, 13, 19, 26, 33, 40, 46 and 52; C-SSRS follow-up will occur on weeks 4, 10, 26, and 52; Amyloid PET imaging follow-up occurs week 26 and 52;

Trial Locations (1)

77074

Clinical Trial Network, Houston

Sponsors
All Listed Sponsors
collaborator

Hope Biosciences Research Foundation

INDUSTRY

lead

Hope Biosciences LLC

INDUSTRY

NCT04228666 - A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy (HB-adMSCs) for the Treatment of Alzheimer's Disease | Biotech Hunter | Biotech Hunter