Avoiding Sentinel Lymph Node Biopsy in Breast Cancer Patients After Neoadjuvant Chemotherapy

NANot yet recruitingINTERVENTIONAL
Enrollment

340

Participants

Timeline

Start Date

January 31, 2020

Primary Completion Date

January 31, 2025

Study Completion Date

July 31, 2027

Conditions
Breast CancerTriple Negative Breast CancerHER2-positive Breast CancerSentinel Lymph Node
Interventions
PROCEDURE

Omission of sentinel lymph node biopsy

No sentinel lymph node biopsy will be performed in clinically node-negative triple-negative or HER2-positive breast cancer patients with a radiologic complete response on MRI. Participants will be asked to complete quality of life questionnaires at baseline (prior to surgery), 6 months, 1, 3 and 5 years follow-up. A control group consisting of 100 clinically node-negative patients receiving standard treatment will be used to compare QoL scores. This group consists of patients that do not wish to participate in the experimental group (i.e., no sentinel node lymph node biopsy) or patients that are not eligible.

All Listed Sponsors
lead

The Netherlands Cancer Institute

OTHER