A Monotherapy in Subjects With Advanced Solid Tumors

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

September 1, 2019

Primary Completion Date

December 30, 2025

Study Completion Date

December 30, 2026

Conditions
Solid Tumor, Adult
Interventions
DRUG

Highly selective FGFR1-3 inhibitor

All subjects in each cohort will receive a single oral dose of 3D185, followed by a 7-day washout period (i.e. single-dose PK study period). Then, subjects will receive consecutive daily doses (Once daily \[QD\], 28 days/cycle) until disease progression, death, unacceptable toxicity, or withdraw of informed consent, whichever comes first. The dose limiting toxicity (DLT) evaluation period includes the single-dose PK study period and the first treatment cycle (within 35 days after the first dose). The enrolled subjects will be sequentially assigned to the planned dose cohorts according to the protocol and receive 3D185 treatment to observe the occurrence of DLT.

Trial Locations (2)

90403

Sarcoma Oncolog Research Center, Santa Monica

Unknown

Shanghai East Hospital, Shanghai

All Listed Sponsors
lead

3D Medicines (Beijing) Co., Ltd.

INDUSTRY