Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease

PHASE3TerminatedINTERVENTIONAL
Enrollment

236

Participants

Timeline

Start Date

November 11, 2020

Primary Completion Date

August 1, 2023

Study Completion Date

November 6, 2024

Conditions
Sickle Cell Disease
Interventions
DRUG

Voxelotor

Participants are randomized 1:1 to receive voxelotor or placebo.

DRUG

Placebo

Matching placebo.

Trial Locations (29)

100

Gertrude's Children Hospital, Nairobi

11481

King Abdullah International Medical Research Center (KAIMR) Ministry of National Guard - Health, Riyadh

11562

Abu El Rich Hospital, Cairo University Hospital, Cairo

11566

Ain Shams University Hospital-Clinical Research Center (MASRI), Cairo

19104

The Children's Hospital of Philadelphia, Philadelphia

20010

Children's National Medical Center, Washington D.C.

21131

Alexandria Clinical Research Center, Faculty of Medicine, Alexandria University, Alexandria

29425

Medical University of South Carolina, Charleston

30303

Children's Healthcare of Atlanta: Hughes Spalding, Atlanta

33136

University of Miami, Miami

35128

Azienda Ospedaliera Universita (AOU) Padova, Padua

39216

University of Mississippi Medical Center, Jackson

40600

Kemri/Crdr,Siaya,Kemri Clinical Research Annex, Kisumu

50139

Azienda Ospedaliera Universitaria (AOU) Meyer, Florence

77030

Texas Children's Hospital- Wallace Tower, Houston

80138

"Azienda Ospedaliera Universitaria (A.O.U.) Luigi Vanvitelli", Napoli

100254

Lagos University Teaching Hospital, Lagos

200281

College of Medicine, University of Ibadan, Ibadan

460000

University of Nigeria Teaching Hospital, Enugu

700233

Aminu Kano Teaching Hospital, Kano

800242

Barau Dikko Teaching/ Kaduna State University, Kaduna

02115

Boston Children's Hospital, Boston

Unknown

Zagazig University Hospital, Alexandria

Sultan Qaboos University Hospital, Muscat

221-1570

Department of Child Health, University of Ghana Medical School, College of Health Sciences, Accra

00233

Komfo Anokye Teaching Hospital, Kumasi

00100

KEMRI CRDR Clinical Research Annex, Nairobi

00200

Strathmore University Medical Centre, Nairobi

E1 1BB

Barts Health NHS Trust, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY