Safety and Preliminary Effectiveness of BGB-A445 in Combination With Tislelizumab in Participants With Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

204

Participants

Timeline

Start Date

January 30, 2020

Primary Completion Date

January 24, 2025

Study Completion Date

January 24, 2025

Conditions
Advanced Solid TumorNon Small Cell Lung CancerHead and Neck Squamous Cell Carcinoma (HNSCC)Nasopharyngeal Carcinoma (NPC)
Interventions
DRUG

BGB-A445

Administered as specified in the treatment arm

DRUG

tislelizumab

Administered as specified in the treatment arm

Trial Locations (30)

704

National Cheng Kung University Hospital, Tainan City

1023

Auckland City Hospital, Auckland

2148

Blacktown Cancer And Haematology Centre, Blacktown

3000

Peter Maccallum Cancer Centre, Melbourne

3004

Nucleus Network, Melbourne

3168

Monash Health, Clayton

4102

Princess Alexandra Hospital, Brisbane

4217

Pindara Private Hospital, Benowa

6009

Linear Clinical Research, Nedlands

10330

King Chulalongkorn Memorial Hospital (Chulalongkorn University), Bangkok

10400

Ramathibodi Hospital Mahidol University, Bangkok

10408

National Cancer Center (NCC), Goyang-si

13496

Cha Bundang Medical Center, Cha University, Gyeonggido

13620

Seoul National University Bundang Hospital, Seongnam-si

15232

UPMC Hillman Cancer Center (Univ Of Pittsburgh), Pittsburgh

16247

The Catholic University of Korea, St. Vincent's Hospital, Suwon

40002

Srinagarind Hospital (Khon Kaen University), Muang

50603

University of Malaya Medical Centre, Kuala Lumpur

90067

Valkyrie Clinical Trials, Los Angeles

92127

California Cancer Associates for Research & Excellence (cCARE), San Diego

93586

Sarawak General Hospital, Kuching

200032

Affiliated Zhongshan Hospital Of Fudan University, Shanghai

250013

Jinan Central Hospital, Jinan

276001

Linyi Cancer Hospital, Linyi

310000

Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

410011

The Second Xiangya Hospital Of Central South University, Changsha

430022

Union Hospital Of Tongji Medical College, Huazhong University Of Science And Technology, Wuhan

03722

Severance Hospital Yonsei University Health System, Seoul

500-06

Changhua Christian Hospital, Changhua

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT04215978 - Safety and Preliminary Effectiveness of BGB-A445 in Combination With Tislelizumab in Participants With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter