Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

January 23, 2020

Primary Completion Date

August 26, 2021

Study Completion Date

February 23, 2023

Conditions
Metastatic CancerMelanomaGastric CancerGastroesophageal Junction AdenocarcinomaColorectal Cancer
Interventions
BIOLOGICAL

VE800

VE800 is an orally administered (PO) live biotherapeutic product (LBP) consisting of 11 distinct nonpathogenic, nontoxigenic, commensal bacterial strains manufactured under Good Manufacturing Practice (GMP) conditions. These strains were selected for their ability to induce an immune response.

DRUG

Nivolumab

Nivolumab is an approved medication that blocks antibodies for certain types of cancer.

DRUG

Vancomycin Oral Capsule

Vancomycin is an antibiotic used to treat or prevent infection.

Trial Locations (18)

10016

New York University Medical Oncology Associates, New York

10065

Weill Cornell Medicine, New York

15232

UPMC Hillman Cancer Center, Pittsburgh

33612

Moffitt Cancer Center, Tampa

34232

Florida Cancer Specialists, Sarasota

46202

Indiana University Melvin and Bren Simon Cancer Center, Indianapolis

60637

The University of Chicago, Chicago

63110

Washington University School of Medicine Siteman Cancer Center, St Louis

75246

Baylor Scott and White Center for Advanced Heart and Lung Disese, Dallas

84112

Huntsman Cancer Institute and Hospital, Salt Lake City

85258

HonorHealth Research Institute, Scottsdale

90095

University of California Los Angeles, Los Angeles

90404

The Angeles Clinic and Research Institute - West Los Angeles Office, Santa Monica

University of California Los Angeles, Santa Monica

94115

Pacific Hematology Oncology Associates, San Francisco

98104

Swedish Medical Oncology - First Hill, Seattle

07601

John Theurer Cancer Center, Hackensack

02906

The Miriam Hospital, Providence

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Vedanta Biosciences, Inc.

INDUSTRY

NCT04208958 - Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer | Biotech Hunter | Biotech Hunter