Intracorporeal Anastomosis Versus Extracorporeal Anastomosis for Left Colon Cancer

NAActive, not recruitingINTERVENTIONAL
Enrollment

350

Participants

Timeline

Start Date

January 27, 2021

Primary Completion Date

July 3, 2024

Study Completion Date

July 3, 2029

Conditions
Colon Cancer
Interventions
PROCEDURE

laparoscopic assisted left colectomy (extracorporeal anastomosis group)

For patients in the control group, the surgeon uses wound edge protectors to exteriorize the colon through a small incision in the midline of the abdomen. A ruler and methylene blue solution are employed to mark the area for colon resection. This guarantees a 10-cm margin from the tumor. Guided by these markers, the marginal vessels and mesentery are divided outside the body. The method of anastomosis is at the surgeon's discretion. A side-to-side anastomosis (including antiperistaltic, isoperistaltic, or overlapping anastomosis) is recommended. Side-to-end or end-to-end anastomosis (sewn by hand or by inserting a circular stapler through the anus or proximal colon) is also allowed. After completing the anastomosis, the incision is sutured. An abdominal drainage tube is inserted at the end of the operation.

PROCEDURE

total laparoscopic left colectomy (intracorporeal anastomosis group)

In the experimental group, the surgeon will use a 10-cm medical suture and methylene blue solution to mark the resection margin. The marginal vessels and mesentery will be divided inside the body. The proximal and distal colons are resected using a 60mm linear laparoscopic stapler. Side-to-side intracorporeal anastomotic techniques like anti-peristaltic, iso-peristaltic, or overlap methods will be applied. Once the anastomosis is completed, the specimen is retrieved. The surgeon can place the specimen in a sterile plastic bag for retrieval. Alternatively, the surgeon can use a disposable incision retraction fixator to protect the wound. An abdominal drainage tube is inserted.

Trial Locations (12)

130021

the First Hospital of Jilin University, Changchun

Unknown

Beijing Friendship Hospital, Capital Medical University, Beijing

Cancer Hospital, Chinese Academy of Medical Sciences, Beijing

Chinese People's Liberation Army General Hospital, Beijing

Peking Union Medical College Hospital, Beijing

Peking University Cancer Hospital, Beijing

The Third Hospital of Jilin University (China - Japan Union Hospital of Jilin University), Changchun

Daping Hospital of Army Medical University, Chongqing

Nanfang Hospital of Southern Medical University, Guangzhou

Fudan University Shanghai Cancer Center (Cancer Hospital Affiliated to Fudan University), Shanghai

Ruijin Hospital Affiliated to Shanghai Jiao Tong University, Shanghai

Shengjing Hospital Affiliated to China Medical University, Shenyang

All Listed Sponsors
lead

Jilin University

OTHER