A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD

PHASE2RecruitingINTERVENTIONAL
Enrollment

212

Participants

Timeline

Start Date

June 30, 2021

Primary Completion Date

March 31, 2028

Study Completion Date

March 31, 2030

Conditions
HbS DiseaseHemoglobin S DiseaseSickle Cell AnemiaSickle Cell DisordersSickling Disorder Due to Hemoglobin SSickle Cell Disease
Interventions
OTHER

TCRα/β+ and CD19+ depleted haploidentical stem cell transplantation

Haploidentical 5+/10 HSCT from a relative, α/β T-depleted

OTHER

Matched sibling donor transplantation

10/10 HSCT - matched family donor

Trial Locations (9)

40225

NOT_YET_RECRUITING

University Hospital Duesseldorf, Clinic for Pediatric Oncology, - Hemtaology and Clinical Immunology, Düsseldorf

69120

RECRUITING

University Hospital Heidelberg, Department of Pediatric Hematology, Oncology and Immunology, Heidelberg

72076

RECRUITING

University Children's Hospital Tübingen, Tübingen

93053

RECRUITING

University Hospital Regensburg, Dept. of Ped. Hematology, Oncology and Stem Cell Transplantation, Regensburg

Unknown

NOT_YET_RECRUITING

St. Anna Kinderspital, Vienna

NOT_YET_RECRUITING

University Hospital Aachen, Children's Hospital, Aachen

NOT_YET_RECRUITING

Charité University medicine, Clinic for Hematology, Oncology, Berlin

NOT_YET_RECRUITING

University Hospital of Frankfurt, Clinic for Paediatrics and Adolescent Medicine, Frankfurt

97080 Würzburg

RECRUITING

University Children's Hospital Würzburg, Würzburg

All Listed Sponsors
lead

University of Regensburg

OTHER