Recovery of Bladder and Sexual Function After Human Spinal Cord Injury

NARecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

January 4, 2021

Primary Completion Date

January 3, 2026

Study Completion Date

January 3, 2027

Conditions
Urinary Bladder, NeurogenicBlood PressureAutonomic DysreflexiaBowel Incontinence
Interventions
DEVICE

Spinal Cord Epidural Stimulation

For arm 2, optimal stimulation parameters (cathode/anode configuration, stimulation frequency and voltage; placement of electrode from L1 to S1) will be identified for blood pressure and bladder pressure to achieve a bladder capacity in the target normative range of 400-450 mLs. Spinal cord epidural stimulation will then be used in a controlled lab setting for the regulation of blood pressure and heart rate to maintain normative values (target systolic pressure of 110-120 mmHg) and bladder pressure below 10 cmH2O during bladder filling up to the targeted capacity (fill volume of 400 mLs).

Trial Locations (1)

40202

RECRUITING

University of Louisville, Louisville

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

lead

University of Louisville

OTHER