Acalabrutinib in Combination With R-ICE For Relapsed or Refractory Lymphoma

Acalabrutinib 100 mg capsules taken by mouth every 12 hours (PO BID), for a total of 2 daily doses on Days 1 to 21 of each cycle.

Rituximab 375 mg/m2 administered intravenously (IV) on Day 1 of each cycle.

Ifosfamide 5g/m2 administered intravenously (IV) over 24 hours on Day 2 of each cycle.

Carboplatin Area Under the Concentration time Curve (AUC) 5 IV administered intravenously (IV) on Day 2 of each cycle.

Etoposide 100 mg/m2 administered intravenously (IV) on Days 1, 2 and 3 of each cycle.