Denosumab (DMAB) Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis (GIOP): a Pilot Study

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

August 17, 2020

Primary Completion Date

August 31, 2025

Study Completion Date

August 31, 2025

Conditions
Osteoporosis
Interventions
DRUG

DMAB Discontinuation and Switching

"Investigators will test the hypothesis that an increase in bone turnover markers (e.g. CTX and P1NP) in patients currently taking chronic glucocorticoids will be attenuated more in those who switch from denosumab to late zoledronic acid (9 months after last denosumab dose) compared to participants randomized to early zoledronic acid (6 months after last denosumab dose) or weekly alendronate (6 months after last denosumab dose"

Trial Locations (1)

35294

University of Alabama at Birmingham, Birmingham

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Maastricht University

OTHER

collaborator

Vrije Universiteit Brussel

OTHER

collaborator

Amgen

INDUSTRY

lead

University of Alabama at Birmingham

OTHER

NCT04177940 - Denosumab (DMAB) Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis (GIOP): a Pilot Study | Biotech Hunter | Biotech Hunter