Early Bactericidal Activity of TBA-7371 in Pulmonary Tuberculosis

PHASE2CompletedINTERVENTIONAL
Enrollment

93

Participants

Timeline

Start Date

January 16, 2020

Primary Completion Date

October 5, 2022

Study Completion Date

October 5, 2022

Conditions
Pulmonary Tuberculosis
Interventions
DRUG

TBA-7371

Participants will receive TBA-7371 oral suspension 100 milligram (mg) once daily (QD) for 14 days.

DRUG

TBA-7371

Participants will receive TBA-7371 oral suspension 100 mg twice daily (BID) for 14 days.

DRUG

TBA-7371

Participants will receive TBA-7371 oral suspension 200 mg QD for 14 days.

DRUG

TBA-7371

Participants will receive TBA-7371 oral suspension 100 mg three times daily (TID) for 14 days.

DRUG

TBA-7371

Participants will receive TBA-7371 oral suspension 400 mg QD for 14 days.

DRUG

HRZE

Participants will receive Isoniazid \[H\] / rifampicin \[R\] / pyrazinamide \[Z\] / ethambutol \[E\] (HRZE), a fixed dose combination tablet QD for 14 days, based on weight as 40-54 kilograms (kg): 3 tablets; 55-70 kg: 4 tablets and 71 kg and over: 5 tablets.

Trial Locations (4)

2574

Perinatal HIV Research Unit (PHRU), Jouberton

7530

TASK, Bellville

7700

University of Cape Town (UCT) Lung Institute, Mowbray

0087

The Aurum Institute, Pretoria

All Listed Sponsors
lead

Gates Medical Research Institute

OTHER