Quantitative Susceptibility Mapping (QSM) to Guide Iron Chelating Therapy

RecruitingOBSERVATIONAL
Enrollment

42

Participants

Timeline

Start Date

December 16, 2019

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
MRI Scans
Interventions
RADIATION

Quantitative Susceptibility Mapping (QSM) Magnetic Resonance Imaging (MRI)

Investigators will validate hepatic QSM (hQSM) using histological examination and chemical measurement of liver iron concentration (LIC). Patients will undergo clinical MRI in Aim 1. In patients with increased LIC their liver explants will undergo MRI, pathological examination, and chemical determination of the LIC.

RADIATION

R2* Magnetic Resonance Imaging (MRI)

Investigators will be able to validate hQSM in measuring liver iron concentration (LIC) by comparing it to this traditional MRI technique

Trial Locations (2)

10021

RECRUITING

Weill Cornell Medical College, New York

10032

RECRUITING

Columbia University Medical Center, New York

All Listed Sponsors
collaborator

Columbia University

OTHER

collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

lead

Weill Medical College of Cornell University

OTHER