Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

161

Participants

Timeline

Start Date

December 20, 2019

Primary Completion Date

January 30, 2026

Study Completion Date

January 30, 2026

Conditions
Metastatic or Locally Advanced Unresectable Solid Tumors
Interventions
DRUG

M1774

M1774 will be administered orally throughout the study.

DRUG

Niraparib

Niraparib will be administered orally throughout the study.

Trial Locations (16)

75230

Mary Crowley Cancer Research Centers, Dallas

77030

The Methodist Hospital Research Institute, Houston

University of Texas M. D. Anderson Cancer Center - Investigational Cancer Therapeutics, Houston

78758

NEXT Oncology, Austin

02114

Massachusetts General Hospital, Boston

Unknown

Beijing Cancer Hospital, Beijing

National Cancer Center Hospital - Dept of Experimental Therapeutics, Chūōku

National Cancer Center Hospital East - Dept of Experimental Therapeutics, Kashiwa-shi

Hospital Clinic de Barcelona - Servicio de Oncologia, Barcelona

Hospital Universitari Vall d'Hebron - Oncology Dept., Barcelona

Centro Integral Oncologico Clara Campal - Unidad de Fase I-Oncologica, Madrid

Hospital Clinico Universitario de Valencia - Servicio de Hematologia y Oncologia Medica, Valencia

Addenbrooke's Hospital - Dept of Oncology, Cambridge

The Christie Hospital - Dept of Oncology, Manchester

Northern Centre for Cancer Care - Sir Bobby Robson Cancer Trials Research Centre, Newcastle upon Tyne

Royal Marsden Hospital - Dept of Oncology, Sutton

All Listed Sponsors
collaborator

Merck KGaA, Darmstadt, Germany

INDUSTRY

lead

EMD Serono Research & Development Institute, Inc.

INDUSTRY

NCT04170153 - Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301) | Biotech Hunter | Biotech Hunter