Plasma-Adapted First-Line Pembro In NSCLC

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

January 13, 2020

Primary Completion Date

June 1, 2025

Study Completion Date

December 1, 2025

Conditions
NSCLC Stage IVMetastatic Non-Small Cell Lung Cancer
Interventions
DRUG

Pembrolizumab

predetermined dose, once per cycle via IV will be administered every 3 weeks, with 21 consecutive days defined as a treatment cycle.

DRUG

PEMETREXED

administered per standard practice, once per cycle via IV will be administered every 3 weeks, with 21 consecutive days defined as a treatment cycle.

DRUG

CARBOPLATIN

administered per standard practice once per cycle via IV will be administered every 3 weeks, with 21 consecutive days defined as a treatment cycle.

DRUG

PACLITAXEL

administered per standard practice once per cycle via IV will be administered every 3 weeks, with 21 consecutive days defined as a treatment cycle.

DIAGNOSTIC_TEST

InVision

Plasma draw for clinical test performed at C1D1 and C2D1; plasma draw for research testing performed at other timepoints per protocol.

Trial Locations (5)

02115

Brigham and Women's Hospital, Boston

Dana Farber Cancer Institute, Boston

02118

Boston Medical Center, Boston

02135

Dana-Farber at Steward St. Elizabeth's Medical Center, Brighton

02190

Dana-Farber/Brigham and Women's Cancer Center (DF/BWCC) in clinical affiliation with South Shore Hospital, South Weymouth

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Inivata

INDUSTRY

lead

Julia K. Rotow, MD

OTHER

NCT04166487 - Plasma-Adapted First-Line Pembro In NSCLC | Biotech Hunter | Biotech Hunter