Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multiple System Atrophy (HORIZON)

PHASE1RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

July 21, 2022

Primary Completion Date

September 30, 2027

Study Completion Date

September 30, 2027

Conditions
Multiple System Atrophy
Interventions
DRUG

ION464

ION464 will be administered by IT injection.

DRUG

Placebo

ION464-matching placebo will be administered by IT injection.

Trial Locations (14)

6020

RECRUITING

Medizinische Universität Innsbruck, Innsbruck

30625

RECRUITING

Medizinische Hochschule Hannover (MHH), Hanover

31059

RECRUITING

Hopital Purpan, Toulouse

35043

RECRUITING

University Hospital Marburg, Marburg

40225

RECRUITING

Universitaetsklinikum Duesseldorf AoeR, Düsseldorf

69500

RECRUITING

CHU de Lyon - Hospices Civils de Lyon-H6pital Pierre Wertheimer, Neurologique HCL, Lyon

75013

RECRUITING

Groupe Hospitalier Pitie-Salpetriere, Paris

81377

RECRUITING

Klinikum der Universtiatet Muenchen -Campus Grosshadern, München

89081

RECRUITING

Universitaetsklinikum Ulm, Ulm

2674-514

RECRUITING

Hospital Beatriz Ângelo, Loures

WC1N 3BG

RECRUITING

Institute of Neurology & The National Hospital for Neurology and Neurosurgery, London

OX3 9DU

RECRUITING

The John Radcliffe Hospital, Oxford

M6 8HD

RECRUITING

Salford Royal Hospital, Salford

SO16 6YD

RECRUITING

Southampton General Hospital, Southampton

Sponsors
All Listed Sponsors
lead

Ionis Pharmaceuticals, Inc.

INDUSTRY