Evaluation of AL3818 in Combination With Nivolumab in Solid Tumors

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

October 17, 2019

Primary Completion Date

December 31, 2027

Study Completion Date

March 31, 2028

Conditions
Solid Tumor, AdultSoft Tissue SarcomaNon Small Cell Lung CancerSmall Cell Lung Cancer
Interventions
DRUG

AL3818

"AL3818: Part 1 - 12 mg, 10 mg, 8 mg, or 6 mg (by dosing cohort), Part 2 - RP2D (as determined from Part 1).~Administered orally once daily on Days 1-14 per 21 day Cycle."

DRUG

Nivolumab Injection

Nivolumab 240 mg Administered by injection every 2 weeks (Odd Cycles: Days 1 and 15 and Even Cycles Day 8) per 21 day Cycle.

Trial Locations (1)

90403

Sarcoma Oncology Research Center, Santa Monica

Sponsors
All Listed Sponsors
collaborator

Advenchen Laboratories, LLC

INDUSTRY

lead

Sarcoma Oncology Research Center, LLC

OTHER