Improving PRegnancy Outcomes With PReVEntive Therapy in Africa-2 (IMPROVE-2)

PHASE3CompletedINTERVENTIONAL
Enrollment

898

Participants

Timeline

Start Date

November 11, 2019

Primary Completion Date

April 15, 2022

Study Completion Date

August 30, 2022

Conditions
Pregnancy; HIV; Malaria
Interventions
DRUG

Intermittent Preventive Therapy with Dihydroartemisinin-Piperaquine

Monthly DP fixed dose of 3 tablets (40 mg of dihydroartemisinin and 320 mg of piperaquine) daily for three days until delivery. All participants will (continue to) receive daily cotrimoxazole (CTX) (one double-strength tablet of 160mg of sulfamethoxazole and 800mg of trimethoprim) and anti-retroviral drugs.

Trial Locations (1)

40100

Kenya Medical Research Institute, Kisumu

All Listed Sponsors
collaborator

Kenya Medical Research Institute

OTHER

collaborator

Kamuzu University of Health Sciences

OTHER

collaborator

Kenya National AIDS & STI Control Programme

OTHER

collaborator

KEMRI-Wellcome Trust Collaborative Research Program

OTHER

collaborator

Centers for Disease Control and Prevention

FED

collaborator

University of Copenhagen

OTHER

collaborator

University of Cape Town

OTHER

collaborator

University of Massachusetts, Worcester

OTHER

collaborator

University of Toronto

OTHER

collaborator

University of Melbourne

OTHER

collaborator

CardiaBase

OTHER

lead

Liverpool School of Tropical Medicine

OTHER