Testing the Addition of Targeted Radiation Therapy to Surgery and the Usual Chemotherapy Treatment (Pemetrexed and Cisplatin [or Carboplatin]) for Stage I-IIIA Malignant Pleural Mesothelioma

PHASE3TerminatedINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

January 29, 2020

Primary Completion Date

November 20, 2023

Study Completion Date

November 20, 2023

Conditions
Pleural Biphasic MesotheliomaPleural Epithelioid MesotheliomaStage I Pleural Malignant Mesothelioma AJCC v8Stage IA Pleural Malignant Mesothelioma AJCC v8Stage IB Pleural Malignant Mesothelioma AJCC v8Stage II Pleural Malignant Mesothelioma AJCC v8Stage IIIA Pleural Malignant Mesothelioma AJCC v8
Interventions
DRUG

Carboplatin

Intravenously

DRUG

Cisplatin

Intravenously

PROCEDURE

Decortication

Undergo decortication

RADIATION

Intensity-Modulated Radiation Therapy

Daily fractions

DRUG

Pemetrexed

Intravenously

DRUG

Pemetrexed Disodium

Intravenously

RADIATION

Pencil beam scanning proton therapy

Daily fractions

PROCEDURE

Pleurectomy

Undergo pleurectomy

Trial Locations (27)

10029

Mount Sinai Hospital, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Westchester, Harrison

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33607

Moffitt Cancer Center-International Plaza, Tampa

33612

Moffitt Cancer Center - McKinley Campus, Tampa

Moffitt Cancer Center, Tampa

43210

Ohio State University Comprehensive Cancer Center, Columbus

44195

Cleveland Clinic Foundation, Cleveland

55905

Mayo Clinic in Rochester, Rochester

60637

University of Chicago Comprehensive Cancer Center, Chicago

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

M D Anderson Cancer Center, Houston

77079

MD Anderson West Houston, Houston

77384

MD Anderson in The Woodlands, Conroe

77478

MD Anderson in Sugar Land, Sugar Land

77573

MD Anderson League City, League City

98122

Swedish Medical Center-First Hill, Seattle

02115

Brigham and Women's Hospital, Boston

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

H3H 2R9

The Research Institute of the McGill University Health Centre (MUHC), Montreal

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER