Cusatuzumab in Combination With Background Therapy for the Treatment of Participants With Acute Myeloid Leukemia

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

61

Participants

Timeline

Start Date

December 23, 2019

Primary Completion Date

May 15, 2026

Study Completion Date

May 15, 2026

Conditions
Leukemia, Myeloid, Acute
Interventions
DRUG

Cusatuzumab

Cusatuzumab will be administered as a dose of 10mg/kg or 20mg/kg intravenously.

DRUG

Azacitidine

Azacitidine will be administered 75 mg/m\^2 subcutaneously or intravenously.

DRUG

Venetoclax

Venetoclax will be administered orally and the dose will ramp-up to 400 mg.

Trial Locations (23)

3010

INSELSPITAL, Universitätsspital Bern, Bern

9007

Kantonsspital St.Gallen, Sankt Gallen

10021

Weill Cornell Medicine, New York

10065

Memorial Sloan Kettering Cancer Center, New York

14203

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

15232

University of Pittsburgh School of Medicine, Pittsburgh

20246

Universitaetsklinik Hamburg-Eppendorf, Hamburg

40207

Norton Cancer Institute, Louisville

48201

Barbara Ann Karmanos Cancer Institute, Detroit

53226

Wisconsin Medical Center, Milwaukee

77030

The University of Texas MD Anderson Cancer Center, Houston

81377

Klinikum der Universitaet Muenchen, München

91010

City of Hope, Duarte

05401

University of Vermont, Burlington

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 2B7

University of Alberta Hospital, Edmonton

M5G 2M9

University of Toronto, Toronto

H4A 3J1

McGill University Health Centre, Montreal

04103

Universitaetsklinikum Leipzig, Leipzig

31-501

Szpital Uniwersytecki w Krakowie, Krakow

93-513

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, Lodz

02-776

Instytut Hematologii i Transfuzjologii, Warsaw

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

argenx

INDUSTRY

collaborator

Janssen Research & Development, LLC

INDUSTRY

lead

OncoVerity, Inc.

INDUSTRY