Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With an Optimized Background Regimen (OBR) in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

November 21, 2019

Primary Completion Date

October 5, 2020

Study Completion Date

January 31, 2027

Conditions
HIV-1-infection
Interventions
DRUG

Oral Lenacapavir

Tablets administered without regard to food

DRUG

Oral Lenacapavir Placebo

Tablets administered without regard to food

DRUG

Subcutaneous Lenacapavir

Administered in the abdomen via subcutaneous injections

DRUG

Failing ARV Regimen

Failing antiretroviral (ARV) regimen defined by the lack of efficacy. Any combination of approved and unapproved agents that could potentially be part of the failing regimen.

DRUG

Optimized Background Regimen (OBR)

Optimized background regimen as prescribed by the Investigator

Trial Locations (75)

87

Vx Pharma, Pretoria

2013

Perinatal HIV Research Unit (PHRU), Soweto

2092

Helen Joseph Hospital, Johannesburg

4302

Durban International Clinical Research Site, Enhancing Care Foundation, Durban

10048

National Taiwan University Hospital, Taipei

10103

Instituto Dominicano de Estudios Virologicos (IDEV), Santo Domingo

10330

Thai Red Cross AIDS Research Center, Bangkok

10400

Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok

10461

Jacobi Medical Center, The Bronx

10514

Hospital Dr. Salvador Bienvenido Gautier, Santo Domingo

10700

Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok

11000

Bamrasnaradura Infectious Diseases Institute, Nonthaburi

11030

North Shore University Hospital/Division of Infectious Diseases, Manhasset

11355

New York-Presbyterian/Queens, Flushing

13009

Hôpital Sainte-Marguerite, Marseille

19104

Perelman Center for Advanced Medicine at the Hospital of the University of Pennsylvania, Philadelphia

20017

Washington Health Institute, Washington D.C.

20127

Divisione di Malattie Infettive, IRCCS Ospedale San Raffaele, Milan

20146

ICH Study Center GmbH & Co. KG, Hamburg

22003

Clinical Alliance for Research and Education - Infectious Diseases, LLC (CARE-ID), Annandale

22060

Far Eastern Memorial Hospital, New Taipei City

24127

University of Naples Federico II, Bergamo

25100

UOC Malattie Infettive - ASST Spedali Civili Di Brescia - Piazzale Spedali Civili 1, Brescia

28046

Hospital Universitario La Paz, Madrid

28209

Atrium Health- Infectious Disease Consultants, Charlotte

30308

Emory Hospital Midtown Infectious Disease Clinic, Atlanta

30309

Atlanta ID Group, PC, Atlanta

31401

Chatham County Health Department, Savannah

32720

Midland Florida Clinical Research Center, LLC, DeLand

32803

Orlando Immunology Center, Orlando

33004

Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan

33016

Floridian Clinical Research, Hialeah

33139

AIDS Healthcare Foundation - South Beach, Miami Beach

33316

Gary J. Richmond, M.D., P.A., Fort Lauderdale

33401

Triple O Research Institute, P.A., West Palm Beach

33614

St. Joseph's Hospital Comprehensive Research Institute, Tampa

34982

Midway Immunology and Research Center, Ft. Pierce

38163

1265 Union Avenue, 8 East, Memphis

40002

Faculty of Medicine, Khon Kaen University, Khon Kaen

41013

Hospital Universitario Virgen del Rocío, Seville

45122

Universitätsklinikum Essen, Klinik für Dermatologie und Venerologie, Essen

48072

Be Well Medical Center, Berkley

60590

Universitätsklinikum Frankfurt, Medizinische Klinik II, Frankfurt am Main

60613

Howard Brown Health Center, Chicago

60657

Northstar Healthcare, Chicago

63139

Southampton Healthcare, Inc., St Louis

75010

Hôpital Saint-Louis, Paris

75012

Hôpital Saint-Antoine, Paris

75018

Hôpital Bichat-Claude Bernard, Paris

75215

AIDS Arms, Inc. DBA Prism Health North Texas, Dallas

75246

North Texas Infectious Diseases Consultants, P.A., Dallas

75605

DCOL Center for Clinical Research, Longview

77098

The Crofoot Research Center, INC., Houston

77401

St Hope Foundation, Bellaire

78705

Central Texas Clinical Research, Austin

80756

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

81362

Kaohsiung Veterans General Hospital, Kaohsiung City

90036

Ruane Clinical Research Group Inc, Los Angeles

90069

Mills Clinical Research, Los Angeles

92264

Eisenhower Health Center at Rimrock, Palm Springs

95817

One Community Health, Sacramento

1600023

Tokyo Medical University Hospital, Tokyo

1628655

Center Hospital of the National Center for Global Health and Medicine, Tokyo

06510

Yale University; School of Medicine, New Haven

02906

The Miriam Hospital, Providence

V6Z 2C9

Vancouver ID Research and Care Centre Society, Vancouver

M5G 1K2

Maple Leaf Research/Maple Leaf Medical Clinic, Toronto

H2L 4E9

Clinique de médecine urbaine du Quartier Latin, Montreal

K1H 8L6

The Ottawa Hospital, Ottawa

00149

U.O.C. IMMUNODEFICIENZE VIRALI - Istituto Nazionale Malattie Infettive Lazzaro Spallanzani IRCCS, Roma

00168

U.O.C. Malattie Infettive - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome

460-0001

National Hospital Organization Nagoya Medical Center, Nagoya

540-0006

National Hospital Organization Osaka National Hospital, Osaka

08916

Hospital Universitari Germans Trías i Pujol, Badalona

08036

Hospital Clinic de Barcelona, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY