NCT04144933View on ClinicalTrials.gov

Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery

PHASE3RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

May 15, 2021

Primary Completion Date

July 30, 2024

Study Completion Date

August 1, 2024

Conditions
AnesthesiaGeneral AnesthesiaAnalgesics, OpioidOpioid Free AnesthesiaPostoperative IleusColorectal SurgeryLaparoscopic SurgeryAnalgesiaDexmedetomidineLidocaineKetamine
Interventions
DRUG

Acetaminophen, Gabapentin

975 mg, 300 mg

DRUG

Acetaminophen, Gabapentin

975 mg, 300 mg

DRUG

Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine

1.5 mg/kg, 0.5 mcg/kg, 0.5 mg/kg

DRUG

Dexamethasone, Ondansetron

6 mg, 4 mg

DRUG

Sevoflurane, Lidocaine 2% Injectable Solution, Ketamine, Dexmedetomidine, Magnesium Sulfate

Dose titrated to effect, 1.5 mg/kg/hr, 0.15 mg/kg/hr, 0.3 -1 mcg/kg/hr (titrated to effect), 30 mg/kg bolus over 30 minutes

DRUG

Lidocaine 1% Injectable Solution, Sufentanil

0.5 mg/kg, 0.25-0.5 mcg/kg (titrated to effect)

DRUG

Sevoflurane, Sufentanil

Dose titrated to effect, As needed (dose at anesthesiologist's discretion)

Trial Locations (1)

S7N 0W8

RECRUITING

Royal University Hospital, Saskatoon

All Listed Sponsors
lead

University of Saskatchewan

OTHER