Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies

PHASE1RecruitingINTERVENTIONAL
Enrollment

499

Participants

Timeline

Start Date

October 30, 2019

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Advanced Unresectable Solid TumorMetastatic Solid Tumor
Interventions
DRUG

TAB004

Recombinant humanized IgG4κ monoclonal antibody specific to BTLA for injection

DRUG

Toripalimab

a human IgG4k monoclonal antibody that specifically binds to the programmed death 1 (PD-1)

Trial Locations (24)

10021

ACTIVE_NOT_RECRUITING

New York Presbyterian / Weill Cornell Medical Center, New York

11042

NOT_YET_RECRUITING

Northwell Health, New Hyde Park

19107

RECRUITING

Thomas Jefferson University, Philadelphia

21201

RECRUITING

University of Maryland Medical Center, Baltimore

22902

RECRUITING

University of California San Francisco (UCSF) Medical Center-Mission Bay, San Francisco

28078

ACTIVE_NOT_RECRUITING

Carolina BioOncology Institute, Huntersville

30322

RECRUITING

Winship Cancer Institute at Emory University, Atlanta

33432

WITHDRAWN

Boca Raton Clinical Research (BRCR), Boca Raton

35294

RECRUITING

University of Alabama at Birmingham, Birmingham

37203

ACTIVE_NOT_RECRUITING

Sarah Cannon Research Institute, Nashville

43210

RECRUITING

The Ohio State University Wexner Medical Center The James Cancer Hospital and Solove Research Institute, Columbus

45219

SUSPENDED

UC Health - University of Cincinnati Medical Center, Cincinnati

48201

RECRUITING

Karmanos Cancer Institute, Detroit

52242

RECRUITING

University of Iowa Hospitals, Iowa City

53792

RECRUITING

University of Wisconsin, Madison

63110

RECRUITING

Washington University, St Louis

68105

SUSPENDED

University of Nebraska Medical Center, Omaha

77030

RECRUITING

MD Anderson Cancer Center, Houston

85721

RECRUITING

University of Arizona College of Medicine-Tucson, Tucson

90095

RECRUITING

UCLA Health Westwood Cancer Care, Los Angeles

92868

RECRUITING

University of California Irvine (UCI) Medical Center, Orange

94158

RECRUITING

University of California at San Francisio, San Francisco

02114

RECRUITING

Massachusetts General Hospital, Boston

75390-8565

RECRUITING

University of Texas Southwestern Medical Center Harold C. Simmons Comprehensive Cancer Center, Dallas

All Listed Sponsors
collaborator

Shanghai Junshi Bioscience Co., Ltd.

OTHER

collaborator

CTI Clinical Trial and Consulting Services

OTHER

lead

TopAlliance Biosciences

INDUSTRY