7
Participants
Start Date
October 17, 2019
Primary Completion Date
April 30, 2026
Study Completion Date
April 30, 2026
anti-EGFR-bispecific antibody armed activated T-cells
"Phase I:~* First 3 participants, twice weekly infusions of 10\^10 EGFR BATs infusions~* If there is toxicity in 0 or 1 of 3 participants, 3 additional participants will be added to the dose level of up to 10\^10.~* If \>/= 2 of 6 participants experience DLTs, then the dose will be reduced to 7.5 x 10\^9 per infusion~* If only 0 or 1 participants has toxicity in the first 6, then the study will proceed to enroll in the expansion cohort~Expansion cohort:~\- 8 infusions of 7.5 x 10\^9 or 10\^10 EGFR BATs in 22 evaluable participants (including the 6 participants treated at the maximum tolerated dose in Phase I)"
Memorial Sloan Kettering Cancer Center, New York
University of Virginia (Specimen Analysis), Charlottesville
University of Virginia
OTHER
Memorial Sloan Kettering Cancer Center
OTHER