A Study of Armed, Activated T-Cells in Patients With Advanced Pancreatic Cancer

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

October 17, 2019

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2026

Conditions
Pancreatic CancerAdvanced Pancreatic CancerPancreatic AdenocarcinomaPancreatic Neoplasms
Interventions
DRUG

anti-EGFR-bispecific antibody armed activated T-cells

"Phase I:~* First 3 participants, twice weekly infusions of 10\^10 EGFR BATs infusions~* If there is toxicity in 0 or 1 of 3 participants, 3 additional participants will be added to the dose level of up to 10\^10.~* If \>/= 2 of 6 participants experience DLTs, then the dose will be reduced to 7.5 x 10\^9 per infusion~* If only 0 or 1 participants has toxicity in the first 6, then the study will proceed to enroll in the expansion cohort~Expansion cohort:~\- 8 infusions of 7.5 x 10\^9 or 10\^10 EGFR BATs in 22 evaluable participants (including the 6 participants treated at the maximum tolerated dose in Phase I)"

Trial Locations (2)

10065

Memorial Sloan Kettering Cancer Center, New York

22908

University of Virginia (Specimen Analysis), Charlottesville

All Listed Sponsors
collaborator

University of Virginia

OTHER

lead

Memorial Sloan Kettering Cancer Center

OTHER