Personalized Vs. Standard Duration of Dual Antiplatelet Therapy and New-generation Polymer-Free vs- Biodegradable-Polymer DES

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

2,106

Participants

Timeline

Start Date

January 1, 2020

Primary Completion Date

October 24, 2021

Study Completion Date

October 24, 2024

Conditions
Coronary Artery DiseaseAcute Coronary SyndromeChronic Coronary SyndromeMyocardial Infarction
Interventions
DEVICE

Percutaneous coronary intervention with implantation of amphilimus-eluting stents for coronary artery disease.

Implantation of polymer-free, amphilimus-eluting, drug-eluting stents

DEVICE

Percutaneous coronary intervention with implantation of everolimus-eluting stents for coronary artery disease.

Implantation of biodegradable-polymer, everolimus-eluting, drug-eluting stents

DRUG

Personalized DAPT duration

Duration of dual antiplatelet therapy according to DAPT score for 3- or 6- months in patients with low DAPT score (stable CAD or ACS, respectively) or for 24-months in patients with high DAPT score

DRUG

Standard DAPT duration

Duration of dual antiplatelet therapy for 12 months.

Trial Locations (13)

80011

Casa di Cura Villa Dei Fiori, Acerra

80014

Ospedale San Giuliano, Giugliano in Campania

80035

Ospedale Santa Maria della Pietà, Nola

80078

Ospedale S.Maria delle Grazie, Pozzuoli

80131

Federico II University of Naples, Naples

A.O.R.N. A. Cardarelli, Napoli

Ospedale San Giovanni Bosco - ASL Napoli 1, Napoli

80147

Ospedale del Mare, Napoli

81031

Ospedale San Giuseppe Moscati, Aversa

81100

A.O.R.N. Sant'Anna e San Sebastiano, Caserta

83100

A.O.R.N. S.Giuseppe Moscati-Città Ospedaliera, Avellino

84025

"Ospedale Maria SS. Addolorata", Eboli

84131

AOU San Giovanni di Dio e Ruggi d'Aragona, Salerno

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AdvicePharma Group

UNKNOWN

lead

Federico II University

OTHER