A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma

PHASE2RecruitingINTERVENTIONAL
Enrollment

237

Participants

Timeline

Start Date

November 7, 2019

Primary Completion Date

August 4, 2026

Study Completion Date

January 17, 2028

Conditions
Multiple Myeloma
Interventions
DRUG

JNJ-68284528

Participants in Cohorts A,B,C, D, E, F, G, and H will receive JNJ-68284528 intravenously.

DRUG

Lenalidomide

Some participants in Cohort D and all participants in Cohorts E, G, and H will also receive lenalidomide capsules orally.

DRUG

Daratumumab

Participants in Cohorts E, G, and H will also receive daratumumab subcutaneous (SC) injection.

DRUG

Bortezomib

Participants in Cohorts E and H will also receive bortezomib subcutaneously.

DRUG

Dexamethasone

Participants in Cohorts E, G, and H will also receive dexamethasone orally or intravenously.

Trial Locations (47)

3000

ACTIVE_NOT_RECRUITING

UZ Leuven, Leuven

9000

ACTIVE_NOT_RECRUITING

UZ Gent, Ghent

10029

RECRUITING

Mount Sinai Medical Center, New York

10065

ACTIVE_NOT_RECRUITING

Memorial Sloan-Kettering Cancer Center, New York

10467

RECRUITING

Montefiore Medical Center, The Bronx

11211

ACTIVE_NOT_RECRUITING

King Faisal Specialist Hospital & Research Center, Riyadh

14263

COMPLETED

Roswell Park Cancer Institute, Buffalo

15232

RECRUITING

University of Pittsburgh, Pittsburgh

19104

RECRUITING

University of Pennsylvania, Philadelphia

19107

RECRUITING

Thomas Jefferson University, Philadelphia

20246

ACTIVE_NOT_RECRUITING

Universitaetsklinikum Hamburg Eppendorf, Hamburg

22908

RECRUITING

University of Virginia, Charlottesville

23298

RECRUITING

Virginia Commonwealth University - Massey Cancer Center, Richmond

28204

RECRUITING

Levine Cancer Institute, Carolinas HealthCare System, Charlotte

30322

ACTIVE_NOT_RECRUITING

Emory University, Atlanta

31008

ACTIVE_NOT_RECRUITING

Clinica Univ. de Navarra, Pamplona

33612

RECRUITING

Moffitt Cancer Center, Tampa

37007

ACTIVE_NOT_RECRUITING

Hosp Clinico Univ de Salamanca, Salamanca

40207

RECRUITING

Norton Cancer Institute, Louisville

44093

COMPLETED

C.H.U. Hotel Dieu - France, Nantes

44195

COMPLETED

Cleveland Clinic, Cleveland

46202

RECRUITING

Indiana University, Indianapolis

48201

COMPLETED

Barbara Ann Karmanos Cancer Institute, Detroit

52242

RECRUITING

University of Iowa Hospitals and Clinics, Iowa City

52621

COMPLETED

Sheba Medical Center Tel Hashomer, Ramat Gan

53705

RECRUITING

University of Wisconsin Carbone Cancer Center, Madison

55905

RECRUITING

Mayo Clinic Rochester, Rochester

59037

COMPLETED

CHRU de Lille Hopital Claude Huriez, Lille

60611

COMPLETED

Northwestern University, Chicago

60637

ACTIVE_NOT_RECRUITING

University of Chicago, Chicago

63110

ACTIVE_NOT_RECRUITING

Washington University School Of Medicine, St Louis

64239

ACTIVE_NOT_RECRUITING

Tel Aviv Sourasky Medical Center, Tel Aviv

66205

RECRUITING

University of Kansas Cancer Center, Westwood

75390

RECRUITING

University of Texas Southwestern Medical Center, Dallas

75475

COMPLETED

Hopital Saint Louis, Paris

84112

RECRUITING

University of Utah, Salt Lake City

92037

RECRUITING

University Of California San Diego, San Diego

94143

ACTIVE_NOT_RECRUITING

University of California San Francisco, San Francisco

97080

ACTIVE_NOT_RECRUITING

Universitatsklinikum Wurzburg, Würzburg

97239

RECRUITING

Oregon Health And Science University, Portland

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

06510

RECRUITING

Yale University School Of Medicine, New Haven

02115

COMPLETED

Dana Farber Cancer Institute, Boston

07601

COMPLETED

Hackensack University Medical Center, Hackensack

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

1081 HV

ACTIVE_NOT_RECRUITING

VU Medisch Centrum, Amsterdam

9713 GZ

ACTIVE_NOT_RECRUITING

University Medical Center Groningen, Groningen

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY