Study to Evaluate the Performance and Safety of the MARIAL® in Association With PPI Versus PPI Alone

"MARIAL® administration: 1 stick twice daily after meals from day 1 to 28.~Omeprazole administration: 20 mg cps once daily from day 1 to day 28"

Omeprazole administration: 20 mg cps once daily from day 1 to day 28

MARIAL® administration: 1 stick twice daily after meals from day 29 to month 6.