Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies

NACompletedINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

October 22, 2019

Primary Completion Date

December 14, 2021

Study Completion Date

December 14, 2021

Conditions
Hypertrophic CardiomyopathyEndothelial Dysfunction
Interventions
BIOLOGICAL

BNP blood sample test

Performed during normal recommended follow-up of the HCM patients.

DIAGNOSTIC_TEST

Electrocardiogram

Performed during normal recommended follow-up of the HCM patients.

DIAGNOSTIC_TEST

Holter ECG

Performed during normal recommended follow-up of the HCM patients.

DIAGNOSTIC_TEST

Echocardiography

Performed during normal recommended follow-up of the HCM patients. Echocardiography at rest and during exercise.

DIAGNOSTIC_TEST

Air venous plethysmography

Performed specifically for the research. Non invasive, and non painful test evaluating different parameters of venous filling by inflation of an armband around the leg, upright positioning, flexion-extension of the leg. Total duration estimated at 30-45 minute.

DIAGNOSTIC_TEST

Upper member arterial Doppler echography with analysis of FMD

Performed specifically for the research. Measurement of the evolution of brachial artery diameter before and after inflation of a armband during 5 minutes. Non invasive and non painful test, duration 30 minutes.

BIOLOGICAL

Endothelial function biomarkers

Performed specifically for the research. Blood sample test, 5 minutes.

Trial Locations (1)

33604

University Hospital, Bordeaux, Pessac

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Fédération Française de Cardiologie

OTHER

collaborator

Fondation Bordeaux Université

UNKNOWN

collaborator

Amicus Therapeutics

INDUSTRY

lead

University Hospital, Bordeaux

OTHER