Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) Treatment

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

October 15, 2019

Primary Completion Date

October 31, 2025

Study Completion Date

October 31, 2025

Conditions
Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaMantle Cell LymphomaMarginal Zone LymphomaWaldenstrom Macroglobulinemia
Interventions
DRUG

Zanubrutinib

Zanubrutinib (BGB-3111) will be orally administered at a dose of 160 mg twice daily or 320mg once daily until disease progression, unacceptable toxicity, treatment consent withdrawal, or study termination.

Trial Locations (24)

37203

Tennessee Oncology, Pllc Nashville, Nashville

78503

Texas Oncology McAllen South Second Street, McAllen

97401

Oncology Associates of Oregon Willamette Valley Cancer Center, Eugene

80012-5405

Rocky Mountain Cancer Centers (Williams) Usor, Aurora

19713-2055

Christiana Care, Newark

33901-8108

Scri Florida Cancer Specialists South, Fort Myers

32204-1128

St Century Oncology, Jacksonville

33705-1449

Scri Florida Cancer Specialists North, St. Petersburg

60422-2067

Healthcare Research Network Iii, Llc, Flossmoor

55337-6749

Minnesota Oncology Burnsville Clinic, Burnsville

89169-3321

Comprehensive Cancer Centers of Nevada, Las Vegas

07932-1049

Summit Medical Group, Florham Park

07960-6136

Morristown Medical Center, Morristown

11590-5119

Clinical Research Alliance, Inc, Westbury

18015-1153

St Lukes University Health Network, Fountain Hill

19044-2331

Abington Hematology Oncology Associates, Horsham

79106-1781

Texas Oncology Amarillo, Amarillo

78705-1163

Texas Oncology Tyler Longview, Austin

75246-2079

Baylor Research Institute, Dallas

22031-4629

Us Oncology Virginia Cancer Specialists, Pc, Fairfax

23502-2800

Virginia Oncology Associates, Norfolk

98109-4433

Fred Hutchinson Cancer Research Center, Seattle

99208-1129

Medical Oncology Associates, Spokane

53717-1959

Ssm Health Cancer Care Dean Medical Center, Madison

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT04116437 - Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) Treatment | Biotech Hunter | Biotech Hunter