RMT in Combination With Durvalumab + Chemo in Untreated Adenocarcinoma NSCLC. A Randomized Double Blind Phase II Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

82

Participants

Timeline

Start Date

November 30, 2022

Primary Completion Date

January 31, 2028

Study Completion Date

January 31, 2028

Conditions
Adenocarcinoma of LungLung Cancer
Interventions
DRUG

Oral Restorative Microbiota Therapy (RMT) Capsules

Patients with PD-L1 TC expression will receive sixteen doses of oral RMT capsules weekly

DRUG

Durvalumab 1500 mg IV

Patients with PD-L1 TC expression receive durvalumab 1500 mg IV every 4 weeks (Q4W) until disease progression or for a maximum of two years from the 1st dose of durvalumab

DRUG

Cisplatin/pemetrexed or Carboplatin/pemetrexed

Patients with PD-L1 TC receive cisplatin/pemetrexed or carboplatin/pemetrexed given every 3 weeks (Q3W) for 4 cycles followed by pemetrexed maintenance given Q3W

OTHER

Placebo

Sixteen doses of oral placebo capsules given weekly

Trial Locations (10)

55455

RECRUITING

Masonic Cancer Center, University of Minnesota, Minneapolis

55746

RECRUITING

MNCCTN Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

MNCCTN Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

MNCCTN Essentia Health Duluth, Duluth

56401

RECRUITING

MNCCTN Essentia Health St. Joseph's Brainerd Medical Center, Brainerd

56501

RECRUITING

MNCCTN Essentia Health St. Mary's Detroit Lakes Clinic, Detroit Lakes

56542

RECRUITING

MNCCTN Essentia Health Fosston, Fosston

56636

RECRUITING

MNCCTN Essentia Health Deer River, Deer River

85338

NOT_YET_RECRUITING

Dr. Amit Kulkarni, Phoenix

550723

RECRUITING

MNCCTN Essentia Health Sandstone, Sandstone

All Listed Sponsors
lead

Masonic Cancer Center, University of Minnesota

OTHER

NCT04105270 - RMT in Combination With Durvalumab + Chemo in Untreated Adenocarcinoma NSCLC. A Randomized Double Blind Phase II Trial | Biotech Hunter | Biotech Hunter