Transformation of Paralysis to Stepping

EARLY_PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

September 30, 2019

Primary Completion Date

August 31, 2025

Study Completion Date

December 31, 2027

Conditions
Spinal Cord Injuries
Interventions
DRUG

Buspirone

Oral Buspirone 7.5mg - 10mg daily during the treatment phase.

DEVICE

Non-invasive Spinal Cord Stimulation

A non-invasive transcutaneous electrical spinal cord stimulator, which can be used a multiple spinal locations.

DEVICE

Ekso Bionics Exoskeleton

This robotic exoskeleton is designed to assist people with neurological injuries for balance, standing, and stepping overground.

DEVICE

Gravity Neutral Device

This device is used to train and assess non-weight bearing stepping movements. When using the device, participants will be lying on their side with their legs suspended off the end of a table supported by small slings that are anchored securely to the apparatus.

DEVICE

Body Weight Supported Treadmill Training

Participants will be supported by a special harness while they are stepping on a treadmill. Trained technicians or therapists will be assist the trunk and legs during stepping as needed.

DEVICE

Rolling Walker

A standard rolling walker will be used for balance support and stability during stepping overground.

Trial Locations (1)

40202

Frazier Rehabilitation and Neuroscience Institute, Louisville

All Listed Sponsors
collaborator

The National Institute of Neurological Disorders and Stroke (NINDS)

UNKNOWN

collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

lead

University of Louisville

OTHER