Giving Chemotherapy for a Shortened Amount of Time Before a Stem Cell Transplantation

Busulfan 3.2 mg/kg/day, with dose adjustments made according to pharmacokinetic (PK) levels.

Fludarabine (25mg/m2/ day) administered on days -6, -5, -4, -3, and -2.

Melphalan (70mg/m2/day) administered on days -6 and -5.

ATG will be given based on a dynamic nomogram based on the patient's absolute lymphocyte count at the start of conditioning and can result in 2 or 3 days of ATG administration.

Busulfan 0.8 mg/kg every 6 hours x 10 doses, with dose adjustments made according to PK levels.

Allogeneic hematopoietic cell transplantation following the conditioning regimen.