NCT04092270 - A Study Combining the Peposertib (M3814) Pill With Standard Chemotherapy in Patients With Ovarian Cancer With an Expansion in High Grade Serous Ovarian Cancer and Low Grade Serous Ovarian Cancer | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

May 7, 2020

Primary Completion Date

June 1, 2026

Study Completion Date

June 1, 2026

Conditions

Endometrial High Grade Endometrioid AdenocarcinomaFallopian Tube CarcinosarcomaFallopian Tube Clear Cell AdenocarcinomaFallopian Tube Endometrioid AdenocarcinomaFallopian Tube High Grade Serous AdenocarcinomaFallopian Tube Mucinous AdenocarcinomaFallopian Tube Transitional Cell CarcinomaFallopian Tube Undifferentiated CarcinomaFIGO Grade 1 Endometrial Endometrioid AdenocarcinomaFIGO Grade 2 Endometrial Endometrioid AdenocarcinomaOvarian High Grade Serous AdenocarcinomaOvarian Seromucinous CarcinomaOvarian Undifferentiated CarcinomaPlatinum-Sensitive Ovarian CarcinomaPrimary Peritoneal CarcinosarcomaPrimary Peritoneal High Grade Serous AdenocarcinomaPrimary Peritoneal Transitional Cell CarcinomaPrimary Peritoneal Undifferentiated CarcinomaRecurrent Fallopian Tube CarcinomaRecurrent Low Grade Fallopian Tube Serous AdenocarcinomaRecurrent Ovarian CarcinomaRecurrent Ovarian CarcinosarcomaRecurrent Ovarian Clear Cell AdenocarcinomaRecurrent Ovarian Endometrioid AdenocarcinomaRecurrent Ovarian Low Grade Serous AdenocarcinomaRecurrent Ovarian Mucinous AdenocarcinomaRecurrent Ovarian Transitional Cell CarcinomaRecurrent Primary Peritoneal CarcinomaRecurrent Primary Peritoneal Low Grade Serous Adenocarcinoma

Interventions

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT scan

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA scan

DRUG

Pegylated Liposomal Doxorubicin Hydrochloride

Given IV

DRUG

Peposertib

Given PO

Trial Locations (11)

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Westchester, Harrison

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

22908

University of Virginia Cancer Center, Charlottesville

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

43210

Ohio State University Comprehensive Cancer Center, Columbus

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

73104

University of Oklahoma Health Sciences Center, Oklahoma City

80045

UCHealth University of Colorado Hospital, Aurora

02215

Dana-Farber Cancer Institute, Boston

07748

Memorial Sloan Kettering Monmouth, Middletown

All Listed Sponsors

lead

National Cancer Institute (NCI)

NIH