Proportion of Clinical Improvement & Type 1 Interferon (IFN) Score Changes in Idiopathic Uveitis Patients With Interferon Gamma Release Assay (IGRA) Positive

RecruitingOBSERVATIONAL
Enrollment

50

Participants

Timeline

Start Date

October 30, 2019

Primary Completion Date

July 31, 2024

Study Completion Date

July 31, 2024

Conditions
Tuberculosis; Uveitis (Manifestation)Anti-Tuberculous Drug ReactionTuberculous Uveitis
Interventions
DRUG

Fixed drug combination (FDC) of ATT and Oral steroid

"In the first two week, patients receive FDC of ATT only. Oral steroid start to be given in week three.~The ATT regiment is continued for up to 6 months or more, in accordance with WHO guidelines. In the first two months the antibiotic combination given consisted of isoniazid (INH), rifampicin, pyrazinamide, and ethambutol. The next four months or continuation phases, the ATT given is rifampicin and isoniazid.~The following dosage and administration of oral steroids will be given to patients, according to guidelines from the American Journal of Ophthalmologists (Douglas A. Jabs et al, 2000):~Initial dose: 1mg/kg/day, with maximum adult oral dose 60-80 mg/kg and maintenance dose less than or equal to 10 mg/day. The tapering schedule: Over 40 mg/day, decrease by 10 mg/day every 1-2 weeks, 40-20 mg/day, decrease by 5 mg/day every 1-2 weeks, 20-10 mg/day, decrease by 2.5 mg/day every 1-2 weeks, 10-0 mg/day, decrease by 1 to 2.5 mg/day every 1-4 weeks."

Trial Locations (1)

10430

RECRUITING

RSUPN dr. Cipto Mangunkusumo (Cipto Mangunkusumo Hospital), Jakarta Pusat

All Listed Sponsors
lead

Fakultas Kedokteran Universitas Indonesia

OTHER