173
Participants
Start Date
February 26, 2020
Primary Completion Date
May 31, 2026
Study Completion Date
May 31, 2026
Red Blood Cell
Red blood cell exchange transfusions will be performed every 3-6 weeks to maintain a target post-transfusion hemoglobin S level of \<20% and a pre-transfusion hemoglobin S of \<30%.
Standard of care
NHLBI/ASH/ATS Expert Panel recommended guidelines
Icahn School of Medicine at Mount Sinai, New York
Montefiore Medical Center, New York
University of Pittsburgh Medical Center, Pittsburgh
Howard University Center for Sickle Cell Disease, Washington D.C.
University of Maryland, Baltimore
Johns Hopkins University, Baltimore
Virginia Commonwealth University, Richmond
University of North Carolina at Chapel Hill, Chapel Hill
Duke University, Durham
East Carolina University, Greenville
Atrium Health, Charlotte
Emory University, Atlanta
University of Alabama, Tuscaloosa
Ohio State University, Columbus
University Hospitals Cleveland Medical Center, Cleveland
University of Illinois at Chicago, Chicago
Washington University-St. Louis, St Louis
University of Texas Health Science Center at Houston, Houston
UCSF Benioff Children's Hospital Oakland, Oakland
Boston Medical Center, Boston
Hemorio, Rio de Janeiro
Kremlin-Bicêtre, Créteil
Henri Mondor Hopital, Paris
National Heart, Lung, and Blood Institute (NHLBI)
NIH
University of Pittsburgh
OTHER