NCT04083950View on ClinicalTrials.gov

Induction of Gut Permeability by an Oral Vaccine

EARLY_PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

December 4, 2019

Primary Completion Date

January 31, 2022

Study Completion Date

September 30, 2025

Conditions
Intestinal PermeabilityInflammationVaccineTyphoid Fever
Interventions
BIOLOGICAL

Vivotif Typhoid Oral Vaccine

One capsule is swallowed on alternate days, e.g. days 15, 17, 19, and 21, for a total of 4 capsules.

DRUG

Aspirin (Positive Control)

Three tablets (325 mg aspirin in each tablet or 975 mg total) are swallowed on days 2 and 3.

Trial Locations (1)

95616

USDA, ARS, Western Human Nutrition Research Center, Davis

All Listed Sponsors
lead

USDA, Western Human Nutrition Research Center

FED