20
Participants
Start Date
September 17, 2019
Primary Completion Date
February 23, 2028
Study Completion Date
August 31, 2038
ATLCAR.CD30 T cells
Autologous T Lymphocyte Chimeric Antigen Receptor cells targeted against the CD30 antigen at dose of 2 × 10\^8 CAR-T/m\^2 with a maximum dose of 5 × 10\^8 CAR-T cells
Bendamustine
70 mg/m\^2 administered IV for 3 days for lymphodepletion 2-14 days prior to first cell infusion
Fludarabine
30 mg/m\^2 administered IV for 3 days for lymphodepletion 2-14 days prior to first and second cell infusion
Cyclophosphamide
300 mg/m\^2 administered IV for 3 days for lymphodepletion 2-14 days prior to second cell infusion and 2-14 days prior to the first cell infusion for subjects who have previously had hypersensitivity to bendamustine
RECRUITING
Wake Forest Baptist Medical Center, Winston-Salem
RECRUITING
Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill
UNC Lineberger Comprehensive Cancer Center
OTHER