CD30 CAR for Relapsed/Refractory CD30+ T Cell Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

September 17, 2019

Primary Completion Date

February 23, 2028

Study Completion Date

August 31, 2038

Conditions
Peripheral T Cell Lymphoma
Interventions
BIOLOGICAL

ATLCAR.CD30 T cells

Autologous T Lymphocyte Chimeric Antigen Receptor cells targeted against the CD30 antigen at dose of 2 × 10\^8 CAR-T/m\^2 with a maximum dose of 5 × 10\^8 CAR-T cells

DRUG

Bendamustine

70 mg/m\^2 administered IV for 3 days for lymphodepletion 2-14 days prior to first cell infusion

DRUG

Fludarabine

30 mg/m\^2 administered IV for 3 days for lymphodepletion 2-14 days prior to first and second cell infusion

DRUG

Cyclophosphamide

300 mg/m\^2 administered IV for 3 days for lymphodepletion 2-14 days prior to second cell infusion and 2-14 days prior to the first cell infusion for subjects who have previously had hypersensitivity to bendamustine

Trial Locations (2)

27157

RECRUITING

Wake Forest Baptist Medical Center, Winston-Salem

27599

RECRUITING

Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill

All Listed Sponsors
lead

UNC Lineberger Comprehensive Cancer Center

OTHER