Deep rTMS and Varenicline for Smoking Cessation

NACompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

August 22, 2019

Primary Completion Date

September 13, 2022

Study Completion Date

December 30, 2022

Conditions
Tobacco Use DisorderSmoking Cessation
Interventions
DEVICE

Deep Repetitive Transcranial Magnetic Stimulation (Active)

Active deep rTMS (10 Hz) using the H-coil to target the bilateral insula

DEVICE

Deep Repetitive Transcranial Magnetic Stimulation (Sham)

Sham deep rTMS using the H-coil. The sham coil is built into the same helmet as the active coil. It mimics the active coil with regards to acoustics and scalp sensations.

DRUG

Varenicline

12 week course treatment of varenicline (0.5 mg/1 mg) using the standard dosage schedule for smoking cessation (Day 1-3: 0.5 mg daily; day 4-7: 0.5 mg twice a day; day 8-end of treatment: 1 mg twice a day).

Trial Locations (1)

M5S 2S1

Centre for Addiction and Mental Health, Toronto

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

collaborator

Brainsway

INDUSTRY

lead

Centre for Addiction and Mental Health

OTHER

NCT04083144 - Deep rTMS and Varenicline for Smoking Cessation | Biotech Hunter | Biotech Hunter