Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

December 20, 2019

Primary Completion Date

May 31, 2026

Study Completion Date

September 30, 2026

Conditions
Head and Neck Squamous Cell Carcinoma (HNSCC)
Interventions
DRUG

Nivolumab

A fully human anti-programmed death 1 (PD-1) monoclonal antibody checkpoint inhibitor, that blocks a signal that prevents activated T cells from attacking the cancer cells.

DRUG

Relatlimab

A monoclonal antibody with anti-Lymphocyte-activation gene 3 (LAG-3) (immune checkpoint receptor protein found on the cell surface) activity.

DRUG

Ipilimumab

A monoclonal anitibody that targets CTLA-4, a protein receptor, that down regulates the immune system.

Trial Locations (1)

15232

RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Dan Zandberg

OTHER

NCT04080804 - Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer | Biotech Hunter | Biotech Hunter