SCIB1 and iSCIB1+ in Melanoma Patients Receiving Nivolumab With Ipilimumab or SCIB1 With Pembrolizumab (The SCOPE Study)

PHASE2RecruitingINTERVENTIONAL
Enrollment

173

Participants

Timeline

Start Date

August 19, 2019

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Malignant MelanomaMelanoma (Skin)Melanoma Stage IIIMelanoma Stage IV
Interventions
BIOLOGICAL

SCIB1 or iSCIB1+ DNA vaccine

"Participants receive up to 11 doses of either SCIB1 or iSCIB1+ up to 85 weeks, in combination with nivolumab with ipilimumab or SCIB1 with pembrolizumab.~Nivolumab with ipilimumab or pembrolizumab treatment will be started 1 week after the first dose of SCIB1 or iSCIB1+ and given as per standard treatment."

Trial Locations (15)

Unknown

RECRUITING

Cambridge University Hospitals NHS Foundation Trust, Cambridge

RECRUITING

Velindre University NHS Trust, Cardiff

RECRUITING

The Leeds Teaching Hospitals NHS Trust, Leeds

RECRUITING

Guy's & St Thomas' NHS Foundation Trust, London

RECRUITING

Royal Free London NHS Foundation Trust, London

RECRUITING

The Royal Marsden NHS Foundation Trust, London

RECRUITING

The Christie NHS Foundation Trust, Manchester

RECRUITING

East and North Hertfordshire NHS Trust, Northwood

RECRUITING

Nottingham University Hospitals NHS Trust, Nottingham

RECRUITING

Oxford University Hospital NHS Foundation Trust, Oxford

RECRUITING

University Hospital Plymouth NHS Trust, Plymouth

RECRUITING

Lancashire Teaching Hospitals NHS Foundation Trust, Preston

RECRUITING

Sheffield Teaching Hospital NHS Foundation Trust, Sheffield

RECRUITING

University Hospital Southampton NHS Foundation Trust, Southampton

RECRUITING

Somerset NHS Foundation Trust, Taunton

All Listed Sponsors
lead

Scancell Ltd

INDUSTRY