Study of Acalabrutinib Versus Chlorambucil Plus Rituximab in Adult Subjects With Previously Untreated Chronic Lymphocytic Leukemia

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

155

Participants

Timeline

Start Date

January 20, 2020

Primary Completion Date

January 3, 2024

Study Completion Date

January 1, 2027

Conditions
Untreated Chronic Lymphocytic Leukemia
Interventions
DRUG

Acalabrutinib

acalabrutinib 100 mg twice daily orally

DRUG

Rituximab

Rituximab: 375 mg/m2 IV infusion on Day 1 of Cycle 1. 500 mg/m2 IV infusion on Day 1 for each of subsequent cycles (Cycles 2-6)

DRUG

Chlorambucil

Chlorambucil: 0.5 mg/kg body weight orally on Day 1 and Day 15 of Cycles 1-6

Trial Locations (46)

404

Research Site, Taichung

613

Research Site, Chiayi City

704

Research Site, Tainan City

833

Research Site, Kaohsiung City

1000

Research Site, Manila

1112

Research Site, Quezon City

1229

Research Site, Makati

2600

Research Site, Baguio City

6000

Research Site, Cebu

8000

Research Site, Davao City

10002

Research Site, Taipei

10330

Research Site, Bangkok

10400

Research Site, Bangkok

10700

Research Site, Bangkok

11217

Research Site, Taipei

40002

Research Site, Khon Kaen

40705

Research Site, Taichung

50200

Research Site, Chiang Mai

90110

Research Site, Hat Yai

97002

Research Site, Hualien City

100000

Research Site, Hanoi

100191

Research Site, Beijing

110001

Research Site, Shenyang

110016

Research Site, Qingdao

130021

Research Site, Changchun

200025

Research Site, Shanghai

200040

Research Site, Shanghai

200050

Research Site, Shanghai

210029

Research Site, Nanjing

215006

Research Site, Suzhou

221000

Research Site, Xuzhou

230001

Research Site, Hefei

230031

Research Site, Hefei

272100

Research Site, Changzhou

300020

Research Site, Tianjin

310003

Research Site, Hangzhou

330006

Research Site, Nanchang

410013

Research Site, Changsha

450008

Research Site, Zhengzhou

450052

Research Site, Zhengzhou

510100

Research Site, Guangzhou

510515

Research Site, Guangzhou

550004

Research Site, Guiyang

700000

Research Site, Ho Chi Minh City

050020

Research Site, Shijiazhuang

030001

Research Site, Taiyuan

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY