NCT04074668 - Control of Renal Oxygen Consumption, Mitochondrial Dysfunction, and Insulin Resistance | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

January 1, 2020

Primary Completion Date

May 15, 2022

Study Completion Date

November 15, 2022

Conditions

Diabetic Kidney DiseaseType 1 DiabetesDiabetesDiabetes MellitusDiabetes ComplicationsDiabetic NephropathiesType1diabetesDiabetes, AutoimmuneAutoimmune DiabetesJuvenile DiabetesType 1 Diabetes Mellitus

Interventions

DRUG

Aminohippurate Sodium Inj 20%

Diagnostic aid/agent used to measure effective renal plasma flow (ERPF)

DRUG

Iohexol Inj 300 milligrams/milliliter (mg/ml)

Diagnostic aid/agent used to measure glomerular filtration rate (GFR)

RADIATION

PET/CT Scan

Imaging used to visualize the kidneys and quantify renal metabolic activity

PROCEDURE

Renal Biopsy

Minimally invasive outpatient procedure to obtain renal tissue after ultrasound visualization.

Trial Locations (1)

80045

Children's Hospital Colorado, Aurora