Safety and Efficacy of Ponatinib Followed by Imatinib in Patients With Chronic Myelogenous Leukemia in Chronic Phase

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

170

Participants

Timeline

Start Date

November 13, 2019

Primary Completion Date

June 1, 2029

Study Completion Date

June 1, 2029

Conditions
Philadelphia Chromosome Positive CMLBCR-ABL Positive Chronic Myelogenous Leukemia
Interventions
DRUG

Ponatinib

30mg/day; 6 months. Dose adaptation procedures are planned in case of toxicity.

DRUG

Imatinib

400 mg/day; at least 30 months (M7 to M36), then depending of MR4.5 . Dose adaptation procedures are planned in case of toxicity.

Trial Locations (28)

13000

Institut Paoli Calmettes, Marseille

14000

Institut D'Hematologie de Basse Normandie, Caen

25000

Chru Besançon, Besançon

33000

Institut Bergonie, Bordeaux

34000

Hopital Saint Eloi, Montpellier

35000

Chu - Hopital de Pontchaillou, Rennes

38000

CHU de Grenoble, Grenoble

44000

Chu Hotel Dieu, Nantes

54500

CHRU Nancy/Brabois, Vandœuvre-lès-Nancy

63000

Chu D'Estaing, Clermont-Ferrand

67000

Institut de cancérologie Strasbourg Europe, Strasbourg

69008

Centre Léon Bérard, Lyon

74000

Centre Hospitalier Annecy-Genevois, Annecy

75000

Hopital Saintantoine, Paris

80000

Chu Amiens Picardie, Amiens

84000

CH d'Avignon, Avignon

91000

Centre Hospitalier Sud Francilien, Corbeil-Essonnes

94000

Hopital Henri Mondor, Créteil

94800

Hopital Paul Brousse, Villejuif

Unknown

CHU d'Angers, Angers

Chru Brest, Brest

CH de Versailles - Hôpital André Mignot, Le Chesnay

Hôpital Claude Huriez - CHRU de Lille, Lille

CHU Limoges - Hôpital Dupuytren, Limoges

CHU Nîmes Caremeau - Institut de Cancérologie du Gard, Nîmes

Chu Poitiers, Poitiers

Institut de Cancérologie Lucien Neuwirth, Saint-Priest-en-Jarez

Iuct Toulouse - Oncopole, Toulouse

All Listed Sponsors
lead

Centre Leon Berard

OTHER